Motif ID: SOX{8,9,10}.p2

Z-value: 1.488


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX9chr17_+_701171770.381.1e-08Click!
SOX10chr22_-_383805380.212.0e-03Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_103989195 40.647 NM_001823
 CKB
creatine kinase, brain
chr14_-_103989112 40.053 CKB
creatine kinase, brain
chr6_-_128841432 30.126 NM_002844
NM_001135648
 PTPRK

protein tyrosine phosphatase, receptor type, K

chr3_-_149688886 27.767 PFN2
profilin 2
chr1_-_26232890 27.246 NM_001145454
NM_005563
 STMN1

stathmin 1

chr18_-_74729049 24.832 NM_001025081
NM_001025090
NM_001025092
NM_002385
 MBP



myelin basic protein



chr18_-_74728963 24.498 MBP
myelin basic protein
chr2_-_175869910 24.059 NM_001822
NM_001025201
 CHN1

chimerin (chimaerin) 1

chr12_+_120933911 23.698 DYNLL1
dynein, light chain, LC8-type 1
chr19_+_36359346 21.756 NM_001024807
NM_005166
 APLP1

amyloid beta (A4) precursor-like protein 1

chr1_-_85930610 21.245 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_-_26232643 20.675 NM_203401
 STMN1
stathmin 1
chr1_+_151032866 19.575 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr8_+_26435339 19.039 NM_001386
 DPYSL2
dihydropyrimidinase-like 2
chr1_+_151032880 18.881 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr5_+_140739589 18.730 NM_018923
NM_032096
 PCDHGB2

protocadherin gamma subfamily B, 2

chr15_+_52311408 18.709 NM_002748
 MAPK6
mitogen-activated protein kinase 6
chr12_+_120933832 18.314 NM_001037495
NM_003746
 DYNLL1

dynein, light chain, LC8-type 1

chr3_+_39509069 17.746 NM_182935
 MOBP
myelin-associated oligodendrocyte basic protein
chr15_+_52311438 17.697 MAPK6
mitogen-activated protein kinase 6

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 61 entries
enrichment   p-value GO term description
3.54 1.90e-02 GO:0007173 epidermal growth factor receptor signaling pathway
2.97 1.49e-02 GO:0007265 Ras protein signal transduction
2.37 1.52e-04 GO:0007411 axon guidance
2.29 4.30e-02 GO:0048011 nerve growth factor receptor signaling pathway
2.26 3.49e-05 GO:0007409 axonogenesis
2.19 8.67e-05 GO:0048812 neuron projection morphogenesis
2.18 1.19e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
2.16 8.78e-04 GO:0007264 small GTPase mediated signal transduction
2.12 2.86e-02 GO:0051329 interphase of mitotic cell cycle
2.09 1.85e-04 GO:0031175 neuron projection development
2.09 4.26e-02 GO:0051325 interphase
2.03 4.63e-04 GO:0032990 cell part morphogenesis
2.02 7.93e-05 GO:0000278 mitotic cell cycle
2.02 7.90e-04 GO:0048858 cell projection morphogenesis
1.99 2.46e-04 GO:0048666 neuron development
1.97 2.39e-14 GO:0007399 nervous system development
1.96 3.21e-03 GO:0000904 cell morphogenesis involved in differentiation
1.93 5.52e-03 GO:0007417 central nervous system development
1.90 8.19e-03 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
1.88 1.10e-05 GO:0048699 generation of neurons

Gene overrepresentation in compartment category:

Showing 1 to 20 of 35 entries
enrichment   p-value GO term description
4.84 2.40e-02 GO:0032432 actin filament bundle
2.90 4.33e-02 GO:0042470 melanosome
2.90 4.33e-02 GO:0048770 pigment granule
2.52 2.28e-03 GO:0005819 spindle
2.38 1.36e-02 GO:0030424 axon
1.85 2.42e-02 GO:0043005 neuron projection
1.83 2.01e-04 GO:0015630 microtubule cytoskeleton
1.83 3.28e-02 GO:0045202 synapse
1.79 1.96e-03 GO:0030054 cell junction
1.72 4.46e-02 GO:0005730 nucleolus
1.66 5.85e-11 GO:0005829 cytosol
1.63 7.73e-07 GO:0005856 cytoskeleton
1.50 1.93e-02 GO:0044430 cytoskeletal part
1.48 3.86e-08 GO:0043228 non-membrane-bounded organelle
1.48 3.86e-08 GO:0043232 intracellular non-membrane-bounded organelle
1.36 5.13e-03 GO:0044428 nuclear part
1.35 6.03e-13 GO:0044444 cytoplasmic part
1.35 4.31e-03 GO:0043233 organelle lumen
1.35 5.19e-03 GO:0031974 membrane-enclosed lumen
1.35 4.37e-02 GO:0031981 nuclear lumen

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.00 1.64e-02 GO:0003779 actin binding
1.88 1.06e-03 GO:0008092 cytoskeletal protein binding
1.39 7.14e-04 GO:0000166 nucleotide binding
1.37 2.71e-02 GO:0035639 purine ribonucleoside triphosphate binding
1.35 3.68e-02 GO:0017076 purine nucleotide binding
1.35 4.12e-02 GO:0032553 ribonucleotide binding
1.35 4.12e-02 GO:0032555 purine ribonucleotide binding
1.33 1.13e-16 GO:0005515 protein binding
1.16 1.79e-12 GO:0005488 binding